发明名称 |
Pyranones |
摘要 |
A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres, which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyranone is of Formula (1): <IMAGE> Formula (1) wherein: Z is -H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; and Y is optionally substituted hydrocarbyl.
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申请公布号 |
US5443970(A) |
申请公布日期 |
1995.08.22 |
申请号 |
US19920946193 |
申请日期 |
1992.09.17 |
申请人 |
ZENECA LIMITED |
发明人 |
BLACKER, ANDREW J.;CROSBY, JOHN;HERBERT, JOHN A. L. |
分类号 |
C07B61/00;C07D309/30;C07D309/32;C07D309/38;C07F7/18;C12P17/06;C12P41/00;(IPC1-7):C12P17/06 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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