The present invention provides purified and isolated polynucleotides encoding Type I ribosome-inactivating proteins (RIPs) and analogs of the RIPs having a cysteine available for disulfide bonding to targeting molecules. Vectors comprising the polynucleotides and host cells transformed with the vectors are also provided. The RIPs and RIP analogs are particularly suited for use as components of cytotoxic therapeutic agents of the invention which include gene fusion products and immunoconjugates. Cytotoxic therapeutic agents or immunotoxins according to the present invention may be used to selectively eliminate any cell type to which the RIP component is targeted by the specific binding capacity of the second component of the agent, and are suited for treatment of diseases where the elimination of a particular cell type is a goal, such as autoimmune disease, cancer and graft-versus-host disease.
申请公布号
WO9426910(A1)
申请公布日期
1994.11.24
申请号
WO1994US05348
申请日期
1994.05.12
申请人
XOMA CORPORATION;BETTER, MARC, D.;CARROLL, STEPHEN, F.;STUDNICKA, GARY, M.
发明人
BETTER, MARC, D.;CARROLL, STEPHEN, F.;STUDNICKA, GARY, M.