1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents

摘要

Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols of the formula RCH(OR1)CH(NR2R3)R4 or RCH2CR35(NR2R3)R4 wherein R is <IMAGE> CH3(CH2)mC 3BOND C, CH3(CH2)mCH=CH,CH3(CH2)mCH2CH2, <IMAGE> <IMAGE> <IMAGE> <IMAGE> wherein m is 3 to 15, n is 0 to 12, and W and X are independently hydrogen, hydroxy, alkyl, alkoxy, halogen, or trifluoromethyl, <IMAGE> wherein R23 loweralkyl; Z is S, O, or C=O; and A is S or O; R1, R2, R3, R4, R35 and R40 are as defined in the specification, the optical isomers thereof, or the pharmaceutically acceptable salts thereof, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.