Oxazinone derivative

摘要

PCT No. PCT/JP92/00444 Sec. 371 Date Dec. 10, 1992 Sec. 102(e) Date Dec. 10, 1992 PCT Filed Apr. 9, 1992 PCT Pub. No. WO92/18488 PCT Pub. Date Oct. 29, 1992.Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: <IMAGE> [I] where A includes, for example, <IMAGE> in which W is -O-, -S-, -CH=CH- or -NR9- or means that (CH2)n is directly bonded to (CH2)n, V2 is =CR12- or =N-, and D is 5 to 7-membered carbon ring or hetero ring; X is -O-, -S-, -CO-, or -NR15 or means that A is directly bonded to (CH2)l; Y is -O-, -CH=CH- or -NR16- or means that (CH2)l is directly bonded to Z; Z is -CH2- or -CO-; and l is an integer of 0 to 4. Further, R and R1 to R16 are hydrogen atom, lower alkyl group, etc.