| 摘要 |
Virus filtering a soln. contg. at least one macromolecule where the total salt content of the soln. is 0.2M upto the satn. of the soln. is claimed. The total salt content of the soln. is pref. 0.4-2.5 (pref. 0.6-2.0) M and the salt is NaCl, KCl, NaOAc and/or sodium citrate. The macromolecule is a protein, polysaccharide and/or polypeptide esp. Factor IX, gammaglobulin, albumin, antithrombin III, or a deletion deriv. of recombinant factor VIII. The method is carried out in accordance with the 'dead'end' filtering technique and the process reduces the content of non-enveloped viruses by /- 4 logs. |
