| 摘要 |
The present invention provides mutants mass-producing epsilon PL which are obtained by mutation treatment of a strain producing epsilon PL. For using the mutants, the mutants are cultured in a cultivated medium, epsilon PL is mass-produced and stored in the culture solution, and the stored epsilon PL is collected from the solution. For producing epsilon PL, a strain which produces epsilon PL is mutation-treated, the obtained mutant is cultivated in a culture medium to which L-lysine or L-lysine and one or more sugars are added, epsilon PL is mass-produced and stored in the culture solution, and the stored epsilon PL is collected from the solution. The mutants producing epsilon PL in large quantities are preferably the mutants which have tolerance to an analogue of L-lysine of Streptomyces albulus subsp. lysinopolymerus No. 346-D strain and chloramphenicol-treated mutant of the same bacteria.
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