发明名称 DERIVATIVES OF BENZIMIDAZOLE AND THEIR USE AS ANTIHISTAMINES
摘要 The present invention relates to novel compounds derived from benzimidazole, characterized in that they correspond to the formula I, or their therapeutically acceptable salts, <IMAGE> I in which: R1 and R2, equal or different, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxy radical, an alkoxy radical, an alkyl carboxylate radical, an aryl or substituted aryl radical, n may have the values 0 or 1, m may have the values 2 to 4, X, Y, Z and W, equal or different, represents a nitrogen atom or a carbon atom bonded to a hydrogen atom, a halogen or another alkyl, aryl, alkoxycarbonyl, carboxy, hydroxyl, sulfonic and alkylsulfonic radical. The present invention relates also to the treatment of various allergic disorders caused by histamine.
申请公布号 US5182280(A) 申请公布日期 1993.01.26
申请号 US19910735653 申请日期 1991.07.25
申请人 LABORATORIOS DEL DR. ESTEVE, S. A. 发明人 CUBERES-ALTISENT, MARIA R.;FRIGOLA-CONSTANSA, JORDI;PARES-COROMINAS, JUAN
分类号 A61K31/495;A61K31/496;A61P37/08;A61P43/00;C07D207/325;C07D231/10;C07D233/54;C07D235/14;C07D249/04;C07D249/08;C07D257/04;C07D259/00;C07D295/12;C07D403/12;C07D403/14;C07D521/00 主分类号 A61K31/495
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