Process for the production of antibiotic R106 by a strain of Aureobasidium pullulans

摘要

An antibiotic R106 represented by the general formula (I): <IMAGE> (I) wherein: R is methyl or ethyl; X1 is MePhe, beta -HOMePhe or Phe; X2 is allo-Ile, Val or Leu; X3 is MeVal or Val; X4 is beta -HOMeVal, gamma HOMeVal, MeVal, Val, N, beta -MeAsp, beta -HOMePhe, MePhe, MeDH2,3Val or MeDH3,4Val is produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.