Process for preparing polynucleotides

摘要

This invention is a process for the production of oligonucleotides which comprises: (a) converting an inorganic polymer into a coupling agent-polymer; (b) combining the coupling agent-polymer with a blocked nucleoside to obtain a blocked nucleoside-modified support; and (c) removing the blocking group from the blocked nucleoside-modified support to provide for the coupling of nucleotides to the nucleoside-modified support.