| 摘要 |
<p>Described is a new process for preparing 3-oxo-4-aza-androst-1-ene 17 beta -ketones. The process involves converting the corresponding 17 beta -alkyl carboxylate to the N-methoxy-N-methyl carboxamide and reacting this with an appropriate Grignard reagent to form the desired ketone. The reaction can be conducted in "one pot", thus eliminating isolation of intermediates and avoiding the use of less stable intermediates, e.g., acid chlorides, acyl imidazolides and the like.</p> |
