SLOW RELEASE COMPOSITIONS

摘要

Lithium titanate is made by heating to a temperature of at least 715 DEG C, powder form lithium carbonate and titanium dioxide whilst mixing, for instance in a rotary kiln. The product is formulated into extended release oral pharmaceutical compositions. Lithium ions are released by zero order rate characteristics from the compositions. The composition can have increased density to extend retention in the stomach. The compositions are used for treatment of manic depressive illness.