New mixts. of heparin-based sulphated polysaccharide(s) - are used to prevent post-operative and arterial thrombosis and has longer half-life than known heparin prod

摘要

Mixed sulphated polysaccharides (A) having the basic structure of heparin-forming polysaccharides are characterised by a wt. average mol. wt. (Mw) below that of heparin; 9-20% chains have mol. wt. below 2000 and 5-20% chains have mol. wt. over 8000. The ratio Mw:number average mol. wt. (Mn) is 1.3-1.6. Pref. (A) contains less than 2% dermatan sulphate and has Mw 3500-5500. The polysaccharide chain has at one end 2-O-sulpho-4-enopyranosuronic acid.