| 发明名称 |
Furano[2,3-F]isoindoles as aldose reductase inhibitors. |
| 摘要 |
<p>The present invention relates to a novel aldose reductase inhibitor of the formula: <CHEM> wherein X is methylene or carbonyl; R is <CHEM> R<1>, R<2>, R<3>, and R<4> are each hydrogen or lower alkyl, to a method for producing the inhibitor by culturing Crucibulum sp. RF-3817 or its variants, and to an agent for inhibiting an aldose reductase comprising the inhibitor.</p> |
| 申请公布号 |
EP0459449(A1) |
申请公布日期 |
1991.12.04 |
| 申请号 |
EP19910108805 |
申请日期 |
1991.05.29 |
| 申请人 |
SHIONOGI SEIYAKU KABUSHIKI KAISHA TRADING UNDER THE NAME OF SHIONOGI & CO. LTD. |
发明人 |
YOSHIDA, TADASHI;KATO, TOSHIYUKI;KAWAMURA, YOSHIMI;MATSUMOTO, KOICHI;ITAZAKI, HIROSHI |
| 分类号 |
A61K31/40;A61P3/08;A61P3/10;A61P27/02;A61P27/12;A61P43/00;C07D491/04;C07D491/048;C12N9/99;C12P17/18;C12Q1/26;C12R1/645 |
主分类号 |
A61K31/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
