| 摘要 |
Disclosed are novel (6-17) beta -endorphin fragments which possess a derivatized lysine at site 9. The peptides have the amino acid sequence according to the general formula: <IMAGE> wherein X is a derivatized lysine, selected from the group Lys-Ac, Lys(Z), des-Lys, A2hy, Nle, Met, Leu or Lys [(ar)alkyl]; R1 is Ser, Ala or Pro; R2 is L-Gln, D-Gln, Glu(tyramine) or iodine-containing derivatives thereof; and R3 is L-Leu, Leu-NHCH3, Met, Phe, Phe(Cl), Phe(I), Cha, Mag, Val, (HO)Leu, Bua or Bug. Methods of making the fragments are also described. |
