NEW CONDENSED DIAZEPINONES,PROCESSES FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS

摘要

Condensed diazepinones of the general formula I in which is one of the divalent radicals X is a =CH- group, a =C-Cl- group or a nitrogen atom, A<1> and A<2> can be lower alkylene radicals, Z can be an oxygen atom or an alkylene chain of 1 to 3 C atoms, R<1> can be lower alkyl, cycloalkyl or (cycloalkyl)-alkyl radicals or hydrogen, R<2> can be lower alkyl or cycloalkyl radicals, R<3> and R<4> can be hydrogen, fluorine, chlorine or bromine atoms or lower alkyl radicals, R<5> can be a hydrogen or chlorine atom or the methyl group, R<6> and R<7> can be hydrogen atoms or lower alkyl radicals and R<7> can additionally be a halogen atom, and their acid addition salts and their possible enantiomers are described; processes for preparing these compounds are also described. The compounds are suitable as vagal pacemakers for the treatment of bradycardias and bradyarrhythmias; they have spasmolytic effects on peripheral organs, especially colon, bladder and bronchi.