发明名称 |
Meningococcus class 1 outer-membrane protein vaccine - useful to immunise against meningococcal disease |
摘要 |
<p>Vaccine against meningococcal disease comprises an outer-membrane vesicle isolated from expressing a homologons and/or heterologons gene encoding at least one meningococcal class I outer-membrane protein (I) or a fragment of oligopeptide contg. an epitope. (I) pref. originates from a mutant meningococcal strain which is negative for Class 2/3 outer membrane protein. Also new is the purified fragment of class 1 outer membrane protein of Neisseria meningitidis, the fragment having a mol. wt. of up to 25 kD and cong. continuous or discontinuous epitopes reactive with bactericidal antibodies against N meningitidis. Also claimed are: isolated nucleic acid encoding (I), an antigenic conjugate of (I) and a carrier protein and a fusion protein comprising a flagellin protein with an aminoacid sequence for an epitope of (I) inserted within it.</p> |
申请公布号 |
NL8900036(A) |
申请公布日期 |
1990.07.16 |
申请号 |
NL19890000036 |
申请日期 |
1989.01.06 |
申请人 |
DE STAAT DER NEDERLANDEN, VERTEGENWOORDIGD DOOR DE MINISTER VAN WELZIJN, VOLKSGEZONDHEID EN CULTUUR TE RIJSWIJK. |
发明人 |
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分类号 |
A61K38/00;A61K39/095;C07K14/22;C07K14/255;C07K16/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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