| 摘要 |
PURPOSE:To easily obtain the titled compound having wide pharmacological actions, together with a cis-isomer, in high yield at a low cost, by reacting 4-hydroxyphenylethanolamine with benzoyl chloride and heating the reaction product. CONSTITUTION:The objective compound of formula IV having pharmacological activities such as anti-inflammatory, analgesic, anti-allergic, platelet coagulation suppressing, antipyretic and remedying effect to circulatory diseases or having an ultraviolet absorbing action can be produced by (1) reacting 4- hydroxyphenylethanolamine hydrochloride of formula I with benzoyl chloride of formula II in an organic amine solvent (preferably pyridine, etc.) under cooling and (2) heating and refluxing the resultant N-[2-hydroxy-2-(4- hydroxyphenyl)ethyl]benzamide of formula III in a high-boiling solvent (preferably xylene, etc.) in the absence or presence of a catalyst (especially preferably in the presence of Al2O3, etc.). |
