| 摘要 |
PURPOSE:To provide a cariostatic agent containing a specific univalent straight- chain saturated aliphatic alcohol, exhibiting growth-inhibition activity against Streptococcus mutans which is a main bacterial strain to cause caries, having low toxicity and useful as a dental antibacterial agent or local disinfectant, etc., for the prevention and remedy of caries. CONSTITUTION:The objective cariostatic agent contains a 9-14C, preferably 11-14C univalent straight-chain saturated aliphatic alcohol. The 9-14C univalent straight-chain saturated aliphatic alcohol is e.g. n-nonyl alcohol, n-decyl alcohol, n-undecyl alcohol, n-dodecyl alcohol, etc. Especially, 12C n-dodecyl alcohol exhibits remarkable growth-inhibiting action against Streptococcus mutans. A cariostatic ointment for oral cavity application can be produced by kneading n-dodecyl alcohol with liquid paraffin, adding white vaseline plastibase and sodium carboxy-methylcellulose to the mixture and kneading the composition. |
