Ethanobenzazepines, a process and intermediates for their preparation and their use as medicaments

摘要

The present invention relates to ethanobenzazepines of the formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="89" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R is hydrogen, halogen or lower alkyl, X is C = 0 or CHOH; Y is COH or a group of the formula COCOR' wherein R' is lower alkyl; and X and Y taken together with their common bond form a group of the formula<!-- EPO <DP n="2"> --><Chemistry id="chema02" num="0002"><Image id="ia02" he="30" wi="38" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sup>2</Sup> and R<Sup>3</Sup> are independently hydrogen, lower alkyl or phenyl; an optical or geometric isomer thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for alleviating pain alone or in combination with inert adjuvants.

The invention relates further to a process for the preparation of the compounds and to intermediates thereof.