| 摘要 |
<p>PROCESS FOR CONTROLLING PATTERNS OF CHEMICAL STIMULI ADMINISTRATION TO BIOLOGIGAL TISSUE A process mimics in-vivo or other conditions to a biological tissue that has been isolated from its natural nutrient supply by controlling the concentration of chemical stimuli delivered to the tissue. The process includes starting with a first known volume of the supportive media, having a known concentration of chemical stimuli affecting the tissue at an initial known point in time. Simultaneously, a first known volume and known amount of the chemical stimuli is removed from affecting the tissue and a second known amount of the chemical stimuli is added in a known volume having a known concentration different than the concentration of the chemical stimuli initially affecting the tissue. The volume of the supportive media is then determined along with the resulting concentrations of the chemical stimuli affecting the tissue. The above steps are repeated resulting in the concentration that affects the tissue being known at each and every point in time. In delivering the chemical stimuli to the tissue, the volume of the supportive media supplied to the tissue, the rate of delivery, rate of removal of the media along with the initial concentration of the chemical stimuli and the concentration of the chemical stimuli being supplied is used to determine a desired administration of the chemical stimuli such that the concentration affecting the tissue emulates the desired fluctuations of the chemical stimuli with respect to time. With these parameters defined, the concentration affecting the tissue with respect to time is known at each and every point in time.</p> |
