摘要 |
Substituted 5H-pyrimido[5,4-b]indoles of Formula I <IMAGE> (I) wherein R2 is halogen; the oxadiazolyl group <IMAGE> wherein R'' is lower alkyl with up to 3 carbon atoms; C1-5-alkyl, cycloalkyl, aralkyl, or aryl; ORI, SOnRI with n being 0, 1, or 2, or <IMAGE> wherein RI is hydrogen, C1-5-alkyl, cycloalkyl, aralkyl, or aryl; <IMAGE> wherein RII and RIII are hydrogen, C1-5-alkyl, C3-5-alkenyl, cycloalkyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; and RA is hydrogen; the oxadiazolyl group <IMAGE> wherein R'' is lower alkyl with up to 3 carbon atoms; halogen, nitro, ORI, SOnRI with n being 0, 1, or 2, <IMAGE> wherein RI is hydrogen, C1-5-alkyl, cycloalkyl, aralkyl, or aryl; <IMAGE> wherein RII and RIII are hydrogen, C1-5-alkyl, cycloalkyl, C3-5-alkenyl, aralkyl, aryl, or, with the connecting N-atom, a 5- or 6-membered heterocyclic ring; or PO(OR)2 wherein R is C1-5-alkyl, exhibit strong affinity for binding to benzodiazepine receptors. The novel compounds are suitable for use in psychopharmaceutical preparations.
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申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
RAHTZ, DIETER;HUTH, ANDREAS;SCHMIECHEN, RALPH;SEIDELMANN, DIETER;KEHR, WOLFGANG;SCHNEIDER, HERBERT H.;BRAESTRUP, CLAUS T. |