发明名称 |
PROCESS FOR THE PREPARATION OF TETRONIC ACID |
摘要 |
Process for the production of tetronic acid from 4-haloacetoacetic ester which begins by converting a 4-haloacetoacetic ester into the corresponding 4-benzyloxyacetoacetic ester. The 4-benzyl ester is then hydrogenolyzed into an intermediate product. The 4-hydroxyacetoacetic ester is converted by treatment with acid into tetronic acid. The 4-hydroxyacetoacetic ester can be isolated before conversion. The 4-benzyloxyacetoacetic ester can be produced by conversion of the 4-haloacetoacetic ester with a metal salt of benzyl alcohol. The hydrogenolysis can be carried out in the presence of an acid, whereby the 4-hydroxyacetoacetic ester forming in situ is rearranged directly into tetronic acid. The hydrogenolysis can be carried out under pressure in the presence of a hydrogenation catalyst. |
申请公布号 |
DE3266346(D1) |
申请公布日期 |
1985.10.24 |
申请号 |
DE19823266346 |
申请日期 |
1982.06.08 |
申请人 |
LONZA AG |
发明人 |
MILLER, RAIMUND, DR.;TENUD, LEANDER, DR. |
分类号 |
C07C59/215;C07C51/367;C07D307/60;(IPC1-7):C07D307/60 |
主分类号 |
C07C59/215 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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