| 摘要 |
<p>Cephalosporins (I; R=H Me, cyclopropy1, OH, OMe, OEt, SH, amino; A=optionally substituted Ph, cyclohexy1, 1-cyclohexeny1, 2,4-cyclohexadieny1, thieny1, fury1; Y=H, OMe; D=H, OH, OAc, O2CNH2, pyridinium, carbamoylpyridinium, heterocyclylthio; E=H, protective group) were prepd. Thus, 5-amino2-cyclopropy1-4-hydroxy-pyrimidine was treated with THF, triethyl amine, and D-α-amino-p-hydroxyphenylacetate to give ureidocarboxylic acid(V), which was reacted with 7-amino-3-acetoxymethyl-ceph-3-em-4-carboxylatebenzhydryl ester and dicyclohexylcarbociimide at 5≰C for 4 hr to give Na-7-{D-d-[C2-cyclopropyl-4-hydroxy -5-pyrimidinyl)-ureido -p-hydroxyphenylacetamido}-3-acetoxymethy1-ceph-3-em-4-carboxylate.</p> |
