发明名称 |
MONOCLONAL ANTIBODY AGAINST HEPATITIS B VIRUS |
摘要 |
<p>The new hybridoma cell lines RF-HBs-1, RF-HBs-2 and RF-BHs-4 each secrete a monoclonal antibody to hepatitis B surface antigen. The production of the antibodies may be carried out in vitro by culturing one of the cell lines or in vivo by establishing one of the cell lines as an ascites tumour in a mouse and isolating antibodies from the ascites fluid or from the serum. The antibodies have therapeutic, preventative, and diagnostic uses in respect of hepatitis B virus infections and can be used to purify hepatitis B surface antigen. The relative specificities of the three monoclonal antibodies make them particularly useful in radiometric assay techniques employing specific combinations of the antibodies in solid phase.</p> |
申请公布号 |
JPS56158718(A) |
申请公布日期 |
1981.12.07 |
申请号 |
JP19810051897 |
申请日期 |
1981.04.08 |
申请人 |
NAT RES DEV |
发明人 |
ARISON HERENA GUTSUDOOORU;JIYOOJI JIYANOSHII;HOWAADO KURISUTOFUAA TOMASU |
分类号 |
C12N15/02;A61K38/00;A61K39/29;A61K39/395;C07K14/02;C07K14/10;C07K14/18;C07K16/00;C07K16/08;C07K19/00;C12P21/08;C12R1/91;G01N33/576;G01N33/577 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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