| 摘要 |
For the Contracting states : BE, CH, DE, FR, GB, IT, LU, NL, SE 1. R-(-)-alpha-[(methylamino)methyl]-9,10- ethanoanthracene-9(10H)-ethanol of the formula I see diagramm : EP0014433,P10,F1 or an acid addition salt thereof. For the designated state : AT 1. A process for the production of R-(-)-alpha-[(methylamino)methyl]-9,10-ethano anthracene-9(10H)-ethanol of the formula I or of an acid addition salt thereof, see diagramm : EP0014433,P12,F1 which process comprises a) resolving the racemic alpha-[methylamino)-methyl]-9,10-ethanoanthracene -9(10-H)-ethanol and isolating R-(-)-alpha-[(methylamino)methyl]-9,10-ethano anthracene-9(10H)-ethanol, if desired in the form of an acid addition salt, or b) reacting a compound of the formula II see diagramm : EP0014433,P12,F2 with a compound of the formula III X2 -CH3 wherein one of X1 and X2 is the amino group and the other is a reactive esterified hydroxyl group, and Y1 is a free hydroxyl group and X1 together with Y1 can also be an epoxy group and A is the 9,10-ethano anthracene-9(10H)-yl radical, or c) in a compound of the formula IV see diagramm : EP0014433,P12,F3 in which at least one of Z1 and Z2 is a removable radical and the other may be hydrogen, or Z1 and Z2 together are a divalent removable radical, and A is the 9,10-ethanoanthracene-9(10H)-yl radical, removing Z1 and/or Z2 . d) reducing a compound which differs from the compound of the formula I only in that, in said compound, a carbon atom adjacent to the nitrogen atom is attached to this latter through a double bond or is substituted by a hydroxyl group or an oxo radical, optionally together with lower alkoxy, or e) adding ethylene to R-alpha-[(methylamino)methyl]-9(10H)- anthracene-ethanol, and if desired, converting the resultant R-(-)-alpha-[(methylamino)methyl]-9,10-ethanoanthracene -9(10H)-ethanol into an acid addition salt and/or liberating the base from a resultant acid addition salt. |
