摘要 |
Novel thiazole derivatives with prostaglandin side chains, of the formula I are prepared starting from acetoacetic ester and 7-carbalkoxyheptanoyl chloride in a 13-stage synthesis, where the individual stages comprise known methods. The synthesis is described in the Patent Claim. The novel compounds exert on certain organs an effect which is similar to but more selective than that of the natural prostaglandins. In addition, they inhibit the activity of those enzymes which promote breakdown of the natural prostaglandins in the organism. |