| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention claims pellet with enterosoluble shell, including ixabepilone with structure (A). Also a capsule containing multiple pellets with enterosoluble shell is claimed. Pellet includes particle with coating, containing main particle and active component layer distributed completely or partially on or in the main particle. Active component layer includes ixabepilone of structure (A) and binding agent. In addition, versions of obtaining pellet with enterosoluble shell are claimed. ^ EFFECT: reduced or prevented ixabepilone powder flaking, possible oral administration of ixabepilone without combined acid-neutralising buffer administration. ^ 14 cl, 4 tbl, 3 ex |
