Automatic closed-loop control adjustments and infusion systems incorporating same

摘要

Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves identifying a condition of the user that is likely to influence a response to the fluid in the body of the user and classifying the condition as a first type of a plurality of types of conditions. After classifying the condition as the first type, the method continues by adjusting control information for operating the infusion device based on the first type and operating the infusion device to deliver the fluid to the user in accordance with the adjusted control information.

主权项

1. An infusion system comprising:
a motor operable to deliver fluid to a user, delivery of the fluid influencing a first condition of the user; a sensing arrangement to obtain a measured value indicative of the first condition of the user; a heart rate sensing arrangement to obtain heart rate measurement data for the user; and a control system coupled to the motor, the heart rate sensing arrangement, and the sensing arrangement to:
determine a heart rate variability metric for the user based on a spectral analysis of the heart rate measurement data;detect a second condition of the user that is likely to influence a response to the fluid in a body of the user based on the heart rate measurement data when a measured heart rate for the user is greater than a first threshold value and the heart rate variability metric is less than a second threshold value;classify the second condition as exercise; andafter classifying the second condition as exercise:
adjust control information for operating the motor, resulting in adjusted control information; andoperate the motor to deliver the fluid to the user based at least in part on the adjusted control information and a difference between a target value for the first condition of the user and the measured value, wherein:
the adjusted control information comprises a decreased gain coefficient; andthe control system determines the decreased gain coefficient by estimating an amount of energy expenditure during the exercise, calculating a change in glycemic level for the user based on the amount of energy expenditure, determining an equivalent insulin amount based on the change in glycemic level, and determining an adjusted proportional gain coefficient based on a first difference between a daily insulin requirement for the user and the equivalent insulin amount.