Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations

摘要

A multi-layered combined rapid and controlled release solid pharmaceutical formulation comprising:
at least one controlled release first layer comprising a physical mixture of a first therapeutic agent, a release rate modifier and a sulfoalkyl ether cyclodextrin for releasing said first therapeutic agent at a controlled rate into a first environment of use; and
at least one rapid release second layer comprising a physical mixture of a second therapeutic agent and a sulfoalkyl ether cyclodextrin for releasing said second therapeutic agent rapidly into a second environment of use;
wherein,
said first and second layers are juxtaposed; and
major portions of each of said first and second therapeutic agents are not complexed with said sulfoalkyl ether cyclodextrin.