S-NITROSOTHIOLS AS AGENTS FOR THE TREATMENT OF CIRCULATORY DYSFUNCTIONS

摘要

The invention relates to novel S-nitrosothiols derived from penicillamine or glutathione of general formula (I), wherein A and B are phenyl groups or together represent a -CH2-Q-CH2- radical forming a six-membered ring in which Q represents an oxygen or sulfur atom or an N-R<3> radical, wherein R<3> is hydrogen or an C1-C4 alkyl group; R<1> is an acyl radical which may be a C1-C5 aliphatic acyl radical or a glutamic acid radical bonded by its non-amino acid carboxyl; R<2> is a hydroxyl group or a glycine radical bonded by peptidic linkage in such a way that R<2> is an hydroxyl group when R<1> is an aliphatic acyl radical and R<2> is a glycine radical when R<1> is a glutamic acid radical. Said novel compounds exhibit vasodilating and blood platelet aggregation inhibiting activity and are useful in the treatment of circulatory system dysfunctions, especially cardiovascular dysfunctions.