PYRAZINO(AZA)INDOLE DERIVATIVES

摘要

A chemical compound of formula (I) wherein: R1 to R3 are independently selected from hydrogen and lower alkyl; X1 is selected from N and C-R4; X2 i s selected from N and C-R5; X3 is selected from N and C-R6; X4 is selected fro m N and C-R7; R4, R5 and R7 are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, alkoxy, aryloxy, alkoyl, aryloyl, arylthio, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino, nitro, cyano, carboalkoxy, carboaryloxy and carbox y; and R6 is selected from hydrogen, halogen, alkyl, aryl, aryloxy, alkylthio, arylthio, alkylsulfoxyl, arylsulfoxyl, alkylsulfonyl, arylsulfonyl, amino, alkylamino, dialkylamino and cyano; with the proviso that R4 to R7 are not a ll selected as hydrogen, and pharmaceutically acceptable salts and addition compounds and prodrugs thereof; use thereof in therapy, particularly for the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabet es inspidus, and sleep apnea, and especially for the treatment of therapy.