| 摘要 |
A novel compound of the formula (1):;wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or the like; R3 is a hydrogen atom, alkyl group, amino group or the like; R4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy. |
| 主权项 |
1. A compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; each of Y and Z is independently selected from a single bond and a divalent peptide group consisting of 1-10 amino acid residues, R1 is hydrogen or alkyl, R2 is hydroxyl, amino, alkylamino or dialkylamino, R3 is hydrogen, alkyl, amino, alkylamino, dialkylamino or substituted or unsubstituted alkylcarbonylamino, R4 is hydrogen, alkyl, carboxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl or a group of the formula (2): wherein W is an amino acid residue, m is 1 or 2, and n is an integer of 0-2, with the proviso that when n is 0, R3 is hydrogen or alkyl, or a pharmaceutically acceptable salt thereof. |
