发明名称 Reduced coenzyme Q10 crystal having excellent stability
摘要 With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.
申请公布号 US9388109(B2) 申请公布日期 2016.07.12
申请号 US201214129003 申请日期 2012.06.21
申请人 KANEKA CORPORATION 发明人 Kawachi Hideo;Kitamura Shiro;Ueda Yasuyoshi
分类号 A61K31/12;C07C49/577;A23L2/52;A23K1/16;A23L1/30;A61K8/34;A61Q19/00;C07C45/81;C07C41/40;C07C41/46;C07C43/23 主分类号 A61K31/12
代理机构 Oblon, McClelland, Maier & Neustadt, L.L.P 代理人 Oblon, McClelland, Maier & Neustadt, L.L.P
主权项 1. A reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles 2θ±0.2° of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° in powder X-ray Cu—Kα diffraction.
地址 Osaka-shi JP