发明名称 |
Reduced coenzyme Q10 crystal having excellent stability |
摘要 |
With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal. |
申请公布号 |
US9388109(B2) |
申请公布日期 |
2016.07.12 |
申请号 |
US201214129003 |
申请日期 |
2012.06.21 |
申请人 |
KANEKA CORPORATION |
发明人 |
Kawachi Hideo;Kitamura Shiro;Ueda Yasuyoshi |
分类号 |
A61K31/12;C07C49/577;A23L2/52;A23K1/16;A23L1/30;A61K8/34;A61Q19/00;C07C45/81;C07C41/40;C07C41/46;C07C43/23 |
主分类号 |
A61K31/12 |
代理机构 |
Oblon, McClelland, Maier & Neustadt, L.L.P |
代理人 |
Oblon, McClelland, Maier & Neustadt, L.L.P |
主权项 |
1. A reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles 2θ±0.2° of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° in powder X-ray Cu—Kα diffraction. |
地址 |
Osaka-shi JP |