| 摘要 |
The present invention provides methods and compositions for treating or preventing skin cancer, in particular melanoma, parakeratosis, improving the skin integrity, the skin barrier function and/or decreasing skin ageing in a mammalian subject, preferably a human subject, the method comprising applying vitamin K1, vitamin K2, Matrix Gla-Protein (MGP) or at least one bioactive peptide derived from MGP in an effective amount to the skin. Preferably, the vitamin K comprises at least one of the long-chain menaquinones MK-7 through MK-10. Preferably, the MGP-derived peptides contain the uncarboxylated Gla-domain of human MGP. |
