The present invention is a composition identified as a region of ralA binding protein 1, wherein the region neighbors a membrane-associated portion of the ralA binding protein 1, reduces transport activity and membrane association of the ralA binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells. Medicines may be in the form of antibodies, si-RNA and small molecules that recognize the region.
申请公布号
WO2007055966(A3)
申请公布日期
2009.04.23
申请号
WO2006US42422
申请日期
2006.11.01
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;AWASTHI, SANJAY;SINGHAL, SHARAD, S.;YADAV, SUSHMA