| 主权项 |
1. A method for the treatment of a pathological disorder that is selected from inflammatory diseases and autoimmune diseases, or for the treatment or prophylaxis of allergy, asthma, graft-versus-host disease or transplant rejection, in a subject in need thereof, wherein the method comprises administering to the subject an antagonistic antibody that binds human OX40, wherein:
the antibody comprises a heavy chain and a light chain, wherein the variable domain of the heavy chain comprises a CDR having the sequence given in SEQ ID NO:1 for CDR-H1, a CDR having the sequence given in SEQID NO:2 or SEQ ID NO:20 for CDR-H2 and a CDR having the sequence given in SEQ ID NO:3 for CDR-H3, and wherein the variable domain of the light chain comprises a CDR having the sequence given in SEQ ID NO:4 or SEQ ID NO:21 for CDR-L1, a CDR having the sequence given in SEQ ID NO:5 for CDR-L2 and a CDR having the sequence given in SEQ ID NO:6 for CDR-L3; or the antibody comprises a heavy chain comprising the sequence given in SEQ ID NO:9 and a light chain comprising the sequence given in SEQ ID NO:7; or the antibody comprises a heavy chain comprising the sequence given in SEQ ID NO:15 and a light chain comprising the sequence given in SEQ ID NO:11. |
