Lead compound for otoprotection: targeting HGF signaling with dihexa

摘要

A novel method of preventing or reducing ototoxicity in vertebrates undergoing treatment with therapeutically effective amounts of platinum-based chemotherapeutic agents such as cisplatin or aminoglycoside antibiotics is disclosed herein. The method(s) comprise administering an effective amount of an otoprotective agent comprising Dihexa prior to, concomitantly with, or subsequently to administration of the platinum-based chemotherapeutic agent or aminoglycoside antibiotic.

主权项

1. A method of treating or preventing hearing loss a subject in need thereof, comprising:
administering to said subject one or more hepatocyte growth factor (HGF) mimics having formulawhere
X═(CH2)m where m is 3-8, or a substituted or unsubstituted phenyl; R1 is a D or L cysteine, phenyalanine, aspartic acid, glutamic acid, serine, tyrosine, homocysteine, homoserine or homophenylalanine amino acid residue; R2 is a D or L isoleucine, leucine or valine amino acid residue; and n ranges from 3-7;and wherein covalent bonds 1, 2 and 3 are either peptide bonds or reduced peptide bonds.