发明名称 |
Method for purification of paclitaxel from paclitaxel-containing materials |
摘要 |
<p>This invention relates to methods for purification of paclitaxel from a paclitaxel-containing material. The method comprises the following steps: (a) extracting a paclitaxel-containing material with an organic solvent to obtain an extract, and concentrating the extract; (b) adding the concentrate with an organic solvent which is not mixed with water to separate an organic solvent phase and then concentrating; (c) subjecting the concentrate to normal phase chromatography to obtain an eluate; (d) dissolving the eluate in an acetone or dichloromethane followed by adding pentane or hexane to form a precipitate; and (e) subjecting the precipitate to high performance liquid chromatography. According to the method of the present invention, paclitaxel of over 99.5% purity can be easily obtained from a Taxus genus plant with a high yield. <IMAGE></p> |
申请公布号 |
EP1550659(A1) |
申请公布日期 |
2005.07.06 |
申请号 |
EP20040258186 |
申请日期 |
2004.12.30 |
申请人 |
SAMYANG GENEX CORPORATION |
发明人 |
PYO, SANG-HYUN;KIM, MOON-SUK;CHO, JIN-SUK;SONG, BONG-KYU;CHOI, HO-JOON |
分类号 |
C07D305/14;(IPC1-7):C07D305/14 |
主分类号 |
C07D305/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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