| 摘要 |
PROBLEM TO BE SOLVED: To provide functionalized chromophoric polymer dots and bioconjugates thereof.SOLUTION: The present invention provides, among other aspects, functionalized chromophoric polymer dots comprising a hydrophobic core and a hydrophilic cap, and bioconjugates thereof. Also provided are improved methods for preparing functionalized chromophoric polymer dots. Methods for in vivo imaging and molecular labeling are also disclosed. In one aspect, the present invention provides a functionalized chromophoric polymer dot having a hydrophobic core and a hydrophilic cap. In one embodiment, a functionalized Pdot comprises a chromophoric polymer, and an amphiphilic molecule having a hydrophobic moiety and a hydrophilic moiety attached to a reactive functional group, where the chromophoric polymer is embedded within the hydrophobic core of the Pdot and a portion of the amphiphilic molecule is embedded within the core of the Pdot, while the reactive functional group is located in the hydrophilic cap. In a preferred embodiment, the chromophoric polymer is a semiconducting polymer.SELECTED DRAWING: Figure 1 |
