发明名称 |
METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF DISORDERS IN PATIENTS WITH ELEVATED LEVELS OF CXCL9 AND OTHER BIOMARKERS |
摘要 |
Methods and compositions for treating hemophagocytic lymphohistiocytosis (HLH) are provided. The disclosure also relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of CXCL9, elevated levels of total IFNγ, and other biomarkers. The disclosure also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of CXCL9 elevated levels of total IFNγ, and other biomarkers using agents that interfere with or otherwise antagonize interferon gamma (IFNγ) signaling, including neutralizing anti-IFNγ antibodies. |
申请公布号 |
WO2016177913(A1) |
申请公布日期 |
2016.11.10 |
申请号 |
WO2016EP60360 |
申请日期 |
2016.05.09 |
申请人 |
NOVIMMUNE SA |
发明人 |
DE MIN, Cristina;FERLIN, Walter;DE BENEDETTI, Fabrizio |
分类号 |
C07K16/24;A61K39/395;G01N33/50 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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