| 摘要 |
PURPOSE:n-Butyl ether is used as a solvent in acetylation of phosphoric acid with acetic anhydride to enable industrially high-efficiency production of the titled compound of high purity which is used as a starting compound for preparation of adenosine triphosphate. CONSTITUTION:At first, n-butyl ether is used as a solvent to effect the acetylation of phosphoric acid with acetic anhydride, preferably at -5-5 deg.C. Aqueous ammonia is added to the reaction mixture to effect neutralization, preferably at a temperature lower than 0 deg.C and the mixture is stood to effect phase separation. The upper n-butyl ether phase is recovered, an alcohol, preferably methanol is added to the aqueous phase to precipitate the objective compound and the precipitate is collected by filtration. The amount of the n-butyl ether used is 1-5pts. per 1pt. of phosphoric acid.
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