PREPARATION OF NON-CRYSTALLINE AND CRYSTALLINE DIHYDRATE FORMS OF AZITHROMYCIN

摘要

The present invention describes new procedures for the preparation of the macrolide azithromycin in its non-cystalline and crystalline dihydrate forms, which are characteriz ed and clearly differentiated by means of the following methods and technique: 1. IR Spectroscopy. 2. Differential Scan Calorimetry (DSC). 3 X-Ray Diffraction. 4. Hygroscopicity. 5. Crystallinity test (Light Polarized Microscopy) (see formula I)