| 摘要 |
<p>1480747 Cephalosporin derivatives BEECHAM GROUP Ltd 19 Dec 1974 [18 Jan 1974 10 April 1974] 02437/74 and 16059/74 Heading C2C Novel compounds I (R<SP>1</SP> is phenyl, cyclohexa-1,4-dienyl, 4-hydroxyphenyl, 3,4-dihydroxyphenyl, 3-chloro-4-hydroxyphenyl, or 2- or 3-thienyl; R<SP>7</SP> is carbamoyloxy or -SR<SP>2</SP>; R<SP>2</SP> is heterocyclyl containing one or more of the atoms N, O and S, or R<SP>2</SP> is 1-3 C alkyl; M is H, a cation, pivaloyloxymethyl,α-pivaloyloxyethyl, phthalidyl or 5,6-dimethoxyphthalidyl; and R<SP>3</SP> is indanyl, phenyl, benzyl, phenyl or benzyl substituted by Cl, Br, F, 1-6 C alkyl, 1-6 C alkoxy, 1-6 C alkanoyl, alkoxycarbonyl, NO 2 or di-(1-6 C alkyl)amino, or R<SP>3</SP> is alkyl optionally substituted by Cl, Br, F, NO 2 , 1-6 C alkoxycarbonyl, 1-6 C alkanoyl or 1-6 C alkoxy) are prepared by reaction of a compound IV. with a thiol R<SP>2</SP>SH or by reaction of a compound V with a reactive N-acylating derivative of an acid VI or with a ketene VII Pharmaceutical compositions useful as antibacterial agents comprise a compound I to gether with a suitable carrier or diluent.</p> |
