| 摘要 |
<p>HEXAHYDRO-4-PHENYL-4-HYDROXY-INDOLINE This invention provides new compounds of formula I, I wherein R1 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, fluorine, chlorine or hydroxy, and R2 is i) alkyl of 1 to 4 carbon atoms, ii) alkenyl or alkynyl of 3 to 7 carbon atoms, wherein the multiple bond is located in a position other than .alpha. to the nitrogen atom to which R2 is bound, iii) cycloalkyl of 5 to 7 carbon atoms, iv) alkyl of 1 to 4 carbon atoms monosubstituted by cycloalkyl of 3 to 7 carbon atoms,v) hydroxyalkyl of 2 to 4 carbon atoms, wherein the hydroxy moiety is attached to a carbon atom other than a carbon atom a to the nitrogen atomo to which R2 is bound, vi) a group -(CH2)p-CO-A, wherein p is a whole number from 1 to 3 and A is alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, or vii) a group wherein R3 and R4, independently, are hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, or halogen, and either X is a direct bond, vinylene or carbonyl and n is a whole number from 1 to 5 or X is -O-, -S-, -SO-, -SO2- or -NR5-, wherein R5 is hydrogen, phenyl, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 4 carbon atoms, and n is a whole number from 2 to 5, useful as anti-depressants and anti-arrhythmics.</p> |
