| 摘要 |
The present invention relates to novel 2-substituted indane-2-mercaptoacetylamide derivatives of the formula wherein B1 and B2 are each independently hydrogen, hydroxy, -OR2 wherein R2 is a C1-C4 alkyl or an Ar-Y group wherein Ar is aryl and Y is a hydrogen or C1-C4 alkyl, or, where B1 and B2 are attached to adjacent carbon atoms, B1 and B2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy; A is a bond, methylene, oxygen, sulfur, NR4 or NCOR5 wherein R4 is hydrogen, a C1-C4 alkyl or an Ar-Y-group and R5 is -CF3, a C1-C10 alkyl or an Ar-Y-group; R1 is hydrogen, acetyl, -CH2OC(O)C(CH3)3 or benzoyl; R3 is hydrogen or -CH2OC(O)C(CH3)3; n is an integer 0 to 3; and Q is a group of the formula or wherein Z is O, NH or S; and m is an integer 1 to 5; which are useful as inhibitors of enkephalinase and ACE.
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