| 摘要 |
<p>NEW MATERIAL:A 2-oxoquinoline derivative of formula I (R<0> is H or lower alkyl; R<1> is H, lower alkyl, lower alkenyl, lower alkynyl, or phenulalkyl; R<2> is lower alkyl; R<3> is halogen, phenyl or phenylalkyl; X and Q are halogen; Y is lower alkylene; Z is -N= or -CH=; n is 0-2; the bond between the 3-and the 4-carbon atoms of the 2-oxoquinoline skeleton is single or double bond). EXAMPLE:4-Phenyl-1-[ 3-( 2-oxo-1, 2, 3, 4-tetrahydroquinolin-7-yloxy )propyl ]-1- methyl-piperazinium iodide. USE:An antihistaminic agent for the remedy of allergic rhinitis, etc. and a central nervous system depressant useful as a preoperative medicine. PROCESS:The compound of formula I is prepared by reacting a novel compound of formula II with a compound of formula R<2>O.</p> |
