| 发明名称 | Method for proliferation of antigen-specific T cells | ||
| 摘要 | The present invention relates to an in vitro method for priming genetically modified T cells suitable for administration to a patient having a tumor. The invention is also directed to the composition obtained by the method and uses thereof. | ||
| 申请公布号 | US9476028(B2) | 申请公布日期 | 2016.10.25 |
| 申请号 | US201214110901 | 申请日期 | 2012.04.12 |
| 申请人 | IMMUNICUM AB | 发明人 | Karlsson-Parra Alex;Wallgren Anna-Carin;Andersson Bengt |
| 分类号 | C12N5/00;C12N5/02;A61K38/00;A61K39/00;C12N5/0783;A61K35/17;C12N5/0784 | 主分类号 | C12N5/00 |
| 代理机构 | Porter Wright Morris & Arthur LLP | 代理人 | Porter Wright Morris & Arthur LLP |
| 主权项 | 1. An in vitro method for priming of genetically modified antigen specific CD4+ and/or CD8+ T cells suitable for administration to a patient having a tumor, said method comprising co-culturing tumor antigen receptor expressing target T cells from the patient to be treated, mature dendritic cells, anti-CD3 antibodies and lymphocytes that have been sensitized against MHC class I and/or MHC class II antigens on antigen presenting cells (APCs), wherein the sensitized lymphocytes are obtained by culturing non-proliferating APCs from a first healthy donor with peripheral blood mononuclear cells (PMBCs) from a second healthy donor. | ||
| 地址 | Gothenburg SE | ||