BIS-ALKOXYL AMIDE ALKYL CATIONIC PEPTIDE LIPIDS, SYNTHESIS METHOD THEREOF, AND APPLICATION THEREOF

摘要

A class of bis-alkoxyl amide alkyl cationic peptide lipids has a chemical structural formula: . After the bis-alkoxyl amide alkyl cationic peptide lipids are dispersed in water, a cationic peptide liposome that has desirable stability, uniform dispersion, an average particle size of approximately 120 nm, and a Zeta potential of 30 mV to 50 mV can be obtained. The liposome is capable of effectively compressing plasmid DNA and siRNA, can realize efficient transfection both in vitro and in vivo, and almost does not produce toxicity to cells and mice, so that the liposome is widely applied to gene delivery as a gene carrier.