Quantitatively Differentiating Cardiac from Non-Cardiac Related Chest Pain and Other Cardiac Diagnostics

摘要

Quantitatively diagnosing ischemia by non-invasively sensing mechanical vibrations from mechanical contraction of a ventricle to measure a time duration of an isovolumetric contraction and a peak endocardial acceleration (PEA) of the heart during the IVCT and calculating a myocardial contractility index (MCI) of the subject, for example MCI=PEA/IVCT. Comparing the MCI of the subject during the sensing period to a baseline MCI which is defined as the baseline MCI of the subject or a representative value of the baseline MCI of a population of subjects less a predetermined value, and then determining by a processor whether the MCI of the subject declined during the sensing period by at least a predetermined amount relative to the baseline MCI. Also allows determination of an amount of viable myocardium, existence of total occlusion of a coronary artery, myocardial infarction and whether thrombolysis has been effective so as to be discontinued.

主权项

1. A method of differentiating diagnostically, non-invasively, between chest pain that is cardiac related and chest pain that is not cardiac related, in a mammalian subject that has a heart, the heart including ventricles, the method comprising:
non-invasively sensing, by a device positioned outside the subject, mechanical vibrations that are from a mechanical contraction of at least one of the ventricles of the heart of the mammalian subject, so as to simultaneously measure (a) IVCT, wherein IVCT is a time duration of an isovolumetric contraction portion of a systole phase of a cardiac cycle of the subject; and (b) a peak endocardial acceleration (PEA) of the heart of the subject during the IVCT; one or more processors calculating a myocardial contractility index (MCI) of the subject such that MCI comprises a ratio of the PEA of the subject to the IVCT of the subject; comparing the MCI of the subject to a baseline MCI, wherein the baseline MCI is one of (i) the baseline MCI of the subject, and (ii) a representative value of the baseline MCI of a population of subjects less a predetermined value; and determining by the one or more processors, whether the MCI of the subject declined by at least a predetermined amount relative to the baseline MCI, and if the MCI of the subject did decline by at least the predetermined amount, either (i) determining that the chest pains are cardiac related or (ii) determining that the chest pains are suspected of being cardiac related.