| 发明名称 |
PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-({1-(3,5-BIS-(TRIFLUOROMETHYL)PHENYL)-ETHOXY}- METHYL -8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS |
| 摘要 |
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations. |
| 申请公布号 |
EP3138836(A1) |
申请公布日期 |
2017.03.08 |
| 申请号 |
EP20160168286 |
申请日期 |
2008.03.20 |
| 申请人 |
OPKO Health, Inc. |
发明人 |
Mergelsberg, Ingrid;Scherer, Dominik Hermann;Huttenloch, Monika Erika;Tsui, Hon-chung;Paliwal, Sunil;Shih, Neng-Yang |
| 分类号 |
C07D211/38;C07D471/10;C07D498/10 |
主分类号 |
C07D211/38 |
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